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  • Tumors with TRK fusions (MSK, 2019): Tumors with TRK fusions based on MSK-IMPACT targeted sequencing.

    Description

    This dataset contains summary data visualizations and clinical data from a broad sampling of tropomyosin receptor kinase (TRK) fusion tumors. The data was gathered utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK), information about mutated genes, patient demographics, and modality. The data set also...

    Subject
    DNA Mutational Analysis
    Oncogene Proteins, Fusion
    Receptor Protein-Tyrosine Kinases
    Receptor, trkA
    Receptor, trkB
    Receptor, trkC
    Access Rights
    Free to All
  • Stat3-Bdnf-TrkB axis promotes alveolar regeneration [scRNA-seq]

    Authors
    Worthen, G Scott
    Paris, Andrew
    Description

    Summary from the GEO: "Regenerating new alveolar epithelium is essential for recovery from many lung diseases. This multi-cellular regenerative process occurs when type II alveolar pneumocytes (AT2), with support from mesenchymal niche cells, proliferate to generate more AT2 cells and transdifferentiate in type I pneumocytes. To elucidate how coordinated events between AT2 cells and mesenchyme restore...

    Subject
    Alveolar Epithelial Cells
    Receptor, trkB
    STAT3 Transcription Factor
    Access Rights
    Free to All
  • Stat3-Bdnf-TrkB axis promotes alveolar regeneration [ATAC-seq]

    Authors
    Worthen, G Scott
    Paris, Andrew
    Description

    Summary from the GEO: "Regenerating new alveolar epithelium is essential for recovery from many lung diseases. This multi-cellular regenerative process occurs when type II alveolar pneumocytes (AT2), with support from mesenchymal niche cells, proliferate to generate more AT2 cells and transdifferentiate in type I pneumocytes. To elucidate how coordinated events between AT2 cells and mesenchyme restore...

    Subject
    Alveolar Epithelial Cells
    Receptor, trkB
    STAT3 Transcription Factor
    Access Rights
    Free to All